PROFOX was first released in 1987 and continues to remain the "gold standard" for oximetry test reporting and analysis. It now supports over 100 different pulse oximeters and capnographs, making it the most widely used pulse oximetry reporting software in the industry. PROFOX is primarily used by hospitals, healthcare facilities, and other healthcare providers that prefer an oximetry software that is local rather than web based, for internal security reasons.

VirtuOx Office Plus Edition is a web-based application hosted by VirtuOx. HIPAA protected data is backed up daily on their secure servers and can be accessed from any PC with an internet connection. Office Plus requires no prescription or patient Assignment of Benefit forms, as these tests are not billed by VirtuOx to the patient or payer. Companies pay a monthly SaaS subscription fee to utilize the software application.